abstract：:The Chinese white pine beetle Dendroctonus armandi Tsai and Li, is arguably the most destructive forest insect in the Qinling Mountains in Northern China. Little is known about the structure of the bacterial communities associated with D. armandi even though this wood-boring insect plays important roles in ecosystem a...

journal_title：International journal of molecular sciences

authors： Hu X,Wang C,Chen H,Ma J

更新日期：2013-10-18 00:00:00

abstract：:Pinellia ternata is an important traditional Chinese medicinal plant. The growth of P. ternata is sensitive to high temperatures. To gain a better understanding of heat stress responses in P. ternata, we performed a comparative proteomic analysis. P. ternata seedlings were subjected to a temperature of 38 °C and sampl...

journal_title：International journal of molecular sciences

authors： Zhu Y,Zhu G,Guo Q,Zhu Z,Wang C,Liu Z

更新日期：2013-10-15 00:00:00

abstract：:Tetraploid black locust (Robinia pseudoacacia L.) is adaptable to salt stress. Here, we compared morphological, physiological, ultrastructural, and proteomic traits of leaves in tetraploid black locust and its diploid relatives under salt stress. The results showed that diploid (2×) plants suffered from greater negati...

journal_title：International journal of molecular sciences

authors： Wang Z,Wang M,Liu L,Meng F

更新日期：2013-10-14 00:00:00

abstract：:Wild barley eibi1 mutant with HvABCG31 gene mutation has low capacity to retain leaf water, a phenotype associated with reduced cutin deposition and a thin cuticle. To better understand how such a mutant plant survives, we performed a genome-wide gene expression analysis. The leaf transcriptomes between the near-isoge...

journal_title：International journal of molecular sciences

authors： Yang Z,Zhang T,Lang T,Li G,Chen G,Nevo E

更新日期：2013-10-14 00:00:00

abstract：:Post-transcriptional regulatory networks are dependent on the interplay of many RNA-binding proteins having a major role in mRNA processing events in mammals. We have been interested in the concerted action of the two RNA-binding proteins hnRNP A1 and HuR, both stable components of immunoselected hnRNP complexes and h...

journal_title：International journal of molecular sciences

authors： Papadodima O,Chatziioannou A,Patrinou-Georgoula M,Kolisis FN,Pletsa V,Guialis A

更新日期：2013-10-11 00:00:00

abstract：:Bacteria belonging to the Pectobacterium genus are the causative agents of the blackleg and soft-rot diseases that affect potato plants and tubers worldwide. In Pectobacterium, the expression of the virulence genes is controlled by quorum-sensing (QS) and N-acylhomoserine lactones (AHLs). In this work, we screened a c...

journal_title：International journal of molecular sciences

authors： des Essarts YR,Sabbah M,Comte A,Soulère L,Queneau Y,Dessaux Y,Hélias V,Faure D

更新日期：2013-10-08 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is characterized by the presence of steatosis, inflammation and hepatocyte injury and constitutes hepatic manifestation of the metabolic syndrome. The pathogenesis of NASH is complex and implicates cross-talk between different metabolically active sites, such as liver and adipose t...

journal_title：International journal of molecular sciences

authors： Vonghia L,Michielsen P,Francque S

更新日期：2013-10-01 00:00:00

abstract：:Chondrocyte apoptosis contributes to the disruption of cartilage integrity in osteoarthritis (OA). Recently, we reported that activation of volume-sensitive Cl- current (ICl,vol) mediates cell shrinkage, triggering apoptosis in rabbit articular chondrocytes. A cyclooxygenase (COX) blocker is frequently used for the tr...

journal_title：International journal of molecular sciences

authors： Kumagai K,Kubo M,Imai S,Toyoda F,Maeda T,Okumura N,Matsuura H,Matsusue Y

更新日期：2013-09-30 00:00:00

abstract：:The aim of this study was to evaluate the in cellulo inhibition of hydrogen-peroxide-induced oxidative stress in skin fibroblasts using different low-molecular-weight polysaccharides (LMPS) prepared from agar (LMAG), chitosan (LMCH) and starch (LMST), which contain various different functional groups (i.e., sulfate, a...

journal_title：International journal of molecular sciences

authors： Chen SK,Hsu CH,Tsai ML,Chen RH,Drummen GP

更新日期：2013-09-25 00:00:00

abstract：:In this report, the use of fluorescence detection coupled capillary electrophoresis (CE-FL) allowed us to fully characterize the antigen-antibody interaction. CE-FL allowed separation of unbound quantum dots (QDs) and ligand bound QDs and also revealed an ordered assembly of biomolecules on QDs. Further, we observed F...

journal_title：International journal of molecular sciences

authors： Wang J,Qiu L,Wang C,Zhang Y,Li J,Xia J,Jiang P

更新日期：2013-09-17 00:00:00

abstract：:Eukaryotic cells express a large variety of RNA binding proteins (RBPs), with diverse affinities and specificities towards target RNAs. These proteins play a crucial role in almost every aspect of RNA biogenesis, expression and function. The heterogeneous nuclear ribonucleoproteins (hnRNPs) are a complex and diverse f...

journal_title：International journal of molecular sciences

authors： Jean-Philippe J,Paz S,Caputi M

更新日期：2013-09-16 00:00:00

abstract：:The interactions between peptides and lipids are of fundamental importance in the functioning of numerous membrane-mediated cellular processes including antimicrobial peptide action, hormone-receptor interactions, drug bioavailability across the blood-brain barrier and viral fusion processes. Moreover, a major goal of...

journal_title：International journal of molecular sciences

authors： Galdiero S,Falanga A,Cantisani M,Vitiello M,Morelli G,Galdiero M

更新日期：2013-09-12 00:00:00

abstract：:Plant phenolics have been for many years a theme of major scientific and applied interest. Grape berry phenolics contribute to organoleptic properties, color and protection against environmental challenges. Climate change has already caused significant warming in most grape-growing areas of the world, and the climatic...

journal_title：International journal of molecular sciences

authors： Teixeira A,Eiras-Dias J,Castellarin SD,Gerós H

更新日期：2013-09-11 00:00:00

abstract：:Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this r...

journal_title：International journal of molecular sciences

authors： Ahmad R,Saleem M,Aloysious NS,Yelumalai P,Mohamed N,Hassan S

更新日期：2013-09-10 00:00:00

abstract：:The present study investigates the photochemical properties of potential photosensitizers for photodynamic therapy, namely four commercial heptamethinecyanine dyes (IR125, IR780, IR813, IR820). Spectroscopic studies were made by means of laser induced fluorescence and laser flash photolysis in order to obtain fluoresc...

journal_title：International journal of molecular sciences

authors： Conceição DS,Ferreira DP,Ferreira LF

更新日期：2013-09-09 00:00:00

abstract：:Staphylococcus aureus AgrC is an important component of the agr quorum-sensing system. AgrC is a membrane-embedded histidine kinase that is thought to act as a sensor for the recognition of environmental signals and the transduction of signals into the cytoplasm. However, the difficulty of expressing and purifying fun...

journal_title：International journal of molecular sciences

authors： Wang L,Quan C,Liu B,Xu Y,Zhao P,Xiong W,Fan S

更新日期：2013-09-06 00:00:00

abstract：:Oligomers are commonly observed intermediates at the initial stages of amyloid fibril formation. They are toxic to neurons and cause decrease in neural transmission and long-term potentiation. We describe an in vitro study of the initial steps in amyloid fibril formation by human stefin B, which proved to be a good mo...

journal_title：International journal of molecular sciences

authors： Taler-Verčič A,Kirsipuu T,Friedemann M,Noormägi A,Polajnar M,Smirnova J,Znidarič MT,Zganec M,Skarabot M,Vilfan A,Staniforth RA,Palumaa P,Zerovnik E

更新日期：2013-09-05 00:00:00

abstract：:Poly(ADP-ribose)polymerase-1 (PARP1) is a nuclear protein implicated in DNA repair, recombination, replication, and chromatin remodeling. The aim of this study was to evaluate possible differences between PARP1(-/-) and wild-type mice regarding induction and repair of DNA lesions in irradiated male germ cells. Comet a...

journal_title：International journal of molecular sciences

authors： Villani P,Fresegna AM,Ranaldi R,Eleuteri P,Paris L,Pacchierotti F,Cordelli E

更新日期：2013-09-04 00:00:00

abstract：:The growth and vascularization of prostate cancer is dependent on interactions between cancer cells and supporting stromal cells. The primary stromal cell type found in prostate tumors is the carcinoma-associated fibroblast, which produces placental growth factor (PlGF). PlGF is a member of the vascular endothelial gr...

journal_title：International journal of molecular sciences

authors： Zins K,Thomas A,Lucas T,Sioud M,Aharinejad S,Abraham D

更新日期：2013-09-03 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) is one of the mechanisms of apoptotic cell death. Inhibiting the apoptosis induced by ERS may be a novel therapeutic target in cardiovascular diseases. Icariin, a flavonoid isolated from Epimedium brevicornum Maxim, has been demonstrated to have cardiovascular protective effects, but...

journal_title：International journal of molecular sciences

authors： Zhang Q,Li H,Wang S,Liu M,Feng Y,Wang X

更新日期：2013-08-30 00:00:00

abstract：:Fourier transform infrared (FTIR) microspectroscopy shows potential as a benign, objective and rapid tool to screen pluripotent and multipotent stem cells for clinical use. It offers a new experimental approach that provides a holistic measurement of macromolecular composition such that a signature representing the in...

journal_title：International journal of molecular sciences

authors： Cao J,Ng ES,McNaughton D,Stanley EG,Elefanty AG,Tobin MJ,Heraud P

更新日期：2013-08-26 00:00:00

abstract：:Immune response plays a fundamental role in protecting the organism from infections; however, dysregulation often occurs and can be detrimental for the organism, leading to a variety of immune-mediated diseases. Recently our understanding of the molecular and cellular networks regulating the immune response, and, in p...

journal_title：International journal of molecular sciences

authors： Curtale G,Citarella F

更新日期：2013-08-22 00:00:00

abstract：:A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4,...

journal_title：International journal of molecular sciences

authors： Bao B,Meng Z,Li N,Meng Z,Zhang L,Cao Y,Yao W,Shan M,Ding A

更新日期：2013-08-20 00:00:00

abstract：:Of the multiple sources of reactive oxygen species (ROS) in the blood vessel, NADPH oxidases are the primary source. Whereas several studies have implicated NADPH oxidases in the initiation of atherosclerosis, their roles in disease progression are incompletely understood. Our objective was to determine the potential ...

journal_title：International journal of molecular sciences

authors： Kinkade K,Streeter J,Miller FJ

更新日期：2013-08-19 00:00:00

abstract：:The mechanisms behind fatigue intensification during cancer therapy remain elusive. The interferon alpha-inducible protein 27 (IFI27) was the most up-regulated gene based on our previous microarray data in fatigued men with non-metastatic prostate cancer receiving localized external beam radiation therapy (EBRT). The ...

journal_title：International journal of molecular sciences

authors： Hsiao CP,Araneta M,Wang XM,Saligan LN

更新日期：2013-08-16 00:00:00

abstract：:We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression. This study investigates if specific AR phosphorylation sites have differing roles in the progression of hormone naïve prostate cancer (HNPC) to castrate resis...

journal_title：International journal of molecular sciences

authors： McCall P,Adams CE,Willder JM,Bennett L,Qayyum T,Orange C,Underwood MA,Edwards J

更新日期：2013-08-13 00:00:00

abstract：:Quorum sensing is an intercellular form of communication that bacteria use to coordinate group behaviors such as biofilm formation and the production of antibiotics and virulence factors. The term quorum sensing was originally coined to describe the mechanism underlying the onset of luminescence production in cultures...

journal_title：International journal of molecular sciences

authors： Verma SC,Miyashiro T

更新日期：2013-08-07 00:00:00

abstract：:The epiphyseal plate is a hyaline cartilage plate that sits between the diaphysis and the epiphysis. The objective of this study was to determine the impact of an injury in the growth plate chondrocytes through the study of histological morphology, immunohistochemistry, histomorphometry and Western Blot analyses of th...

journal_title：International journal of molecular sciences

authors： Musumeci G,Castrogiovanni P,Loreto C,Castorina S,Pichler K,Weinberg AM

更新日期：2013-07-29 00:00:00

abstract：:The genetic basis of the wide variation for nutritional traits in Brassica rapa is largely unknown. A new Recombinant Inbred Line (RIL) population was profiled using High Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) analysis to detect quantitative trait loci (QTLs) controlling seed toc...

journal_title：International journal of molecular sciences

authors： Bagheri H,El-Soda M,Kim HK,Fritsche S,Jung C,Aarts MG

更新日期：2013-07-25 00:00:00

abstract：:Plants infected with DNA viruses produce massive quantities of virus-derived, 24-nucleotide short interfering RNAs (siRNAs), which can potentially direct viral DNA methylation and transcriptional silencing. However, growing evidence indicates that the circular double-stranded DNA accumulating in the nucleus for Pol II...

journal_title：International journal of molecular sciences

authors： Pooggin MM

更新日期：2013-07-24 00:00:00

abstract：:This paper aims at analysing the synthesis of flavonoids, their import and export in plant cell compartments, as well as their involvement in the response to stress, with particular reference to grapevine (Vitis vinifera L.). A multidrug and toxic compound extrusion (MATE) as well as ABC transporters have been demonst...

journal_title：International journal of molecular sciences

authors： Petrussa E,Braidot E,Zancani M,Peresson C,Bertolini A,Patui S,Vianello A

更新日期：2013-07-17 00:00:00

abstract：:Small noncoding RNAs that are 19-23 nucleotides long, known as microRNAs (miRNAs), are involved in almost all biological mechanisms during carcinogenesis. Recent studies show that miRNAs released from live cells are detectable in body fluids and may be taken up by other cells to confer cell-cell communication. These r...

journal_title：International journal of molecular sciences

authors： Huang X,Liang M,Dittmar R,Wang L

更新日期：2013-07-16 00:00:00

abstract：:Triple-negative breast cancer (TNBC) is characterized by the lack of immunohistochemical staining for estrogen receptors (ER), progesterone receptors (PR), and lack of overexpression or amplification of human epidermal growth factor receptor 2 (HER2). Our aim was to investigate the expression of transmembrane protease...

journal_title：International journal of molecular sciences

authors： Cheng D,Kong H,Li Y

更新日期：2013-07-12 00:00:00

abstract：:Cholesteatoma is a destructive and expanding growth of keratinizing squamous epithelium in the middle ear or petrous apex. The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. In this study, comparative proteomic analysis was conducted to investi...

journal_title：International journal of molecular sciences

authors： Ho KY,Yeh TS,Huang HH,Hung KF,Chai CY,Chen WT,Tsai SM,Chang NC,Chien CY,Wang HM,Wu YJ

更新日期：2013-07-11 00:00:00

abstract：:This study investigated the interaction between eupatorin and bovine serum albumin (BSA) using ultraviolet-visible (UV-vis) absorption, fluorescence, synchronous fluorescence, circular dichroism (CD) spectroscopies, and molecular modeling at pH 7.4. Results of UV-vis and fluorescence spectroscopies illustrated that BS...

journal_title：International journal of molecular sciences

authors： Xu H,Yao N,Xu H,Wang T,Li G,Li Z

更新日期：2013-07-09 00:00:00

abstract：:Phytoalexins are antimicrobial substances of low molecular weight produced by plants in response to infection or stress, which form part of their active defense mechanisms. Starting in the 1950's, research on phytoalexins has begun with biochemistry and bio-organic chemistry, resulting in the determination of their st...

journal_title：International journal of molecular sciences

authors： Jeandet P,Clément C,Courot E,Cordelier S

更新日期：2013-07-08 00:00:00

abstract：:Cytokines are signaling proteins that were first characterized as components of the immune response, but have been found to have pleiotropic effects in diverse aspects of body function in health and disease. They are secreted by numerous cells and are used extensively in intercellular communications to produce differe...

journal_title：International journal of molecular sciences

authors： Mousa A,Bakhiet M

更新日期：2013-07-04 00:00:00

abstract：:Calorie restriction (CR) inhibits prostate cancer progression, partially through modulation of the IGF axis. IGF-1 receptor (IGF-1R) blockade reduces prostate cancer xenograft growth. We hypothesized that combining calorie restriction with IGF-1R blockade would have an additive effect on prostate cancer growth. Severe...

journal_title：International journal of molecular sciences

authors： Galet C,Gray A,Said JW,Castor B,Wan J,Beltran PJ,Calzone FJ,Elashoff D,Cohen P,Aronson WJ

更新日期：2013-07-03 00:00:00

abstract：:In this work, we studied the antimicrobial properties of a nanocomposite system based on a lactose-substituted chitosan and silver nanoparticles: Chitlac-nAg. Twofold serial dilutions of the colloidal Chitlac-nAg solution were both tested on Streptococcus mitis, Streptococcus mutans, and Streptococcus oralis planktoni...

journal_title：International journal of molecular sciences

authors： Di Giulio M,Di Bartolomeo S,Di Campli E,Sancilio S,Marsich E,Travan A,Cataldi A,Cellini L

更新日期：2013-06-28 00:00:00

abstract：:Adhesion molecules are known to play an important role in endothelial activation and angiogenesis. Here we determined the functional role of IQGAP1 in the regulation of endothelial adherens junctions. VE-cadherin is found to be associated with actin filaments and thus stable, but IQGAP1 at intercellular junctions is n...

journal_title：International journal of molecular sciences

authors： Yuan Z,Zhang W,Tan W

更新日期：2013-06-27 00:00:00